Eliza

Domestic · line: Blue Eyed Maine Coons (Markiss) · one blue eye · Variant known, this cat untested

Under the variant field this directory proposes, this cat would read DBE 161p. A carrier of a variant nobody has sequenced, on no named line. This is the group bare 161 exists for. The proposal is set out in full here, and no registry issues this field today: it is computed from the record at each build and is not part of any registration.

How this cat is connected to the trait

NO RECORDED PARENT LINK JOINS THIS CAT TO A FOUNDER OR TO A TESTED ANIMAL. What the record rests on instead is the line recorded on it, Blue Eyed Maine Coons (Markiss), which is a source's attribution and not a descent this register can walk; and no recorded parent at all, which is a gap in the sources and not a statement that the cat had none.

No parent is recorded for this cat in the register, so no genealogy can be drawn. That is a gap in the sources, not a statement that the cat had none. Any offspring the register holds are listed below.

More than one variant could be present in this cat

DBE-ALT and DBE-CEL. MORE THAN ONE VARIANT COULD BE PRESENT IN THIS CAT: DBE-ALT, DBE-CEL. It is not established that any of them is, and it is not established that two are. A dominant allele comes from a parent, and this cat's recorded ancestry carries an attribution of each. A CAT HOLDING TWO IS A COMPOUND HETEROZYGOTE, which this survey records as the state associated with deaf and dead kittens, and NOTHING BUT A TEST DISTINGUISHES ONE FROM TWO.

Computed from the recorded parentage at every build, counting both the variants this survey adopts and the ones it records a source claiming and does not adopt. IT IS AN UPPER BOUND AND NOT A FINDING: it says what could be here, never what is.

What is flagged

1. ELIZA. HOMOZYGOUS, NOT COMPOUND HETEROZYGOTE, IN THE BREEDER'S OWN WORDS, AND THE TWO ARE DIFFERENT CLAIMS. Her page says 'the last thing I expected from that pairing was a HOMOZYGOUS KITTEN'. Chart C4 writes 'DBE-CEL & DBE-ALT' beside him. HOMOZYGOUS MEANS TWO COPIES OF ONE ALLELE; COMPOUND HETEROZYGOTE MEANS ONE COPY EACH OF TWO DIFFERENT ONES. This register held the second reading and the breeder states the first. NEITHER IS A GENOTYPE and no laboratory result exists for him | THE WORD HOMOZYGOUS CANNOT BE RIGHT IN ITS STRICT SENSE, AND WHAT IT PROBABLY MEANS IS MORE INTERESTING THAN IF IT WERE. ALT AND CEL ARE ESTABLISHED AS SEPARATE VARIANTS in the published work this register holds: Abitbol and others 2024, 'Different Founding Effects Underlie Dominant Blue Eyes in the Domestic Cat', and 'A PAX3 insertion in the Celestial breed'. His dam KAENA runs to NIKITA'L SEYMOUR, who founds ALT; his sire LAZULI runs to ROXI, who founds CEL. A CAT TAKING ONE COPY FROM EACH IS A COMPOUND HETEROZYGOTE, ONE COPY EACH OF TWO DIFFERENT VARIANTS, AND NOT A HOMOZYGOTE. The breeder is almost certainly using homozygous loosely, to mean TWO DOSES OF DOMINANT BLUE EYE rather than two copies of one allele. THAT IS EXACTLY WHAT CHART C4 SAYS WHEN IT WRITES 'DBE-CEL & DBE-ALT' BESIDE HIM, so the chart and the pedigree agree with each other and the breeder's word is the odd one out | AND IT IS THE CASE THE BREEDING GUIDANCE WARNS ABOUT. Two dominant blue eye variants in one animal is precisely the mating the British Gems article, citing Abitbol, says should never be made. MIYUKI IS SOLID WHITE AND DEAF. Whether that is the consequence of carrying both, or of the white spotting reaching him from three directions, IS THE THING NO ONE CAN SEPARATE WITHOUT A TEST | AND THE COAT SAYS BE CAREFUL, WHICH IS WHY HE WAS TRACED. Four generations above him, WHITE SPOTTING REACHES HIM FROM THREE SEPARATE DIRECTIONS: ELIZA, XSH ns 02 69, A HARLEQUIN and herself coded 69; MARCH NIKITA'L, EUR n 03 62, A BICOLOUR; and NIKITA'L SEYMOUR, XSH ns 03 23 68 on the PawPeds reading, ALSO A BICOLOUR. MIYUKI IS SOLID WHITE AND DEAF. THAT IS ALSO EXACTLY WHAT A CAT CARRYING A GREAT DEAL OF WHITE SPOTTING LOOKS LIKE, and deafness is the classic consequence of white over the ear. HIS WHITENESS AND HIS DEAFNESS ARE NOT BY THEMSELVES EVIDENCE OF A HOMOZYGOUS EYE VARIANT, and a homozygous white-spotting cat and a homozygous eye-variant cat cannot be told apart by looking | WHAT ELSE HE COULD CARRY, ASKED AND ANSWERED. He could carry heavy white spotting from Eliza, March Nikita'l and Seymour. He could carry the 69 that Eliza and Pheer-Ca both show. NOTHING IN HIS RECORDED ANCESTRY SUGGESTS DOMINANT WHITE: no animal above him is coded w. NOTHING SUGGESTS THE POINTED GENE: no 33 anywhere. His four grandparents are Seymour, March Nikita'l, Roxi and an unnamed female the charts draw as '??' | HIS LITTERMATE MOCHI IS THE CONTROL AND IS NOT DEAF. Mochi is mostly white with a coloured patch, the Topaz panda pattern, and hears. TWO KITTENS OF ONE LITTER, BOTH LABELLED THE SAME BY THE CHART, ONE DEAF AND ONE NOT. If the label were a genotype they should not differ, and the amount and placement of white is the obvious thing that does differ | HE WAS NEUTERED AND PLACED, so no offspring will ever settle it. ONLY A TEST ON HIM WILL

A flag is not an error. It marks a place where two sources say different things, or where an attribution cannot be made on the evidence held.

The record

Register id

bem-02

Sex

female

Breed, as stated

Domestic

Line

Blue Eyed Maine Coons (Markiss)

Eye status

odd: one blue eye

Eyes, in the source's words

odd

Role

founder

Relations named by the source

a foundation animal. THE PAWPEDS SHEET FOR NIKITA'L MARKISS SHOWS BOTH PARENT CELLS ABOVE THIS ANIMAL AS 'No information in the database', so no further ancestry exists to be found

Country

Russia

EMS code

XSH ns 02 69

The code read out

experimental shorthair; black silver; harlequin; dominant odd eyes, written in the 68 series

The description held

XSH ns 02 69, A HARLEQUIN WITH A DOMINANT ODD EYE. THE 02 IS THE SECOND HIGHEST GRADE OF CLASSIC WHITE SPOTTING and she is a great-granddam of Miyuki of Aerlin, who is solid white and deaf. SHE IS ONE OF THREE ROUTES BY WHICH WHITE SPOTTING REACHES HIM. She is also the dam of Nikita'l Seymour, so her 02 sits at the top of the ALT material

Evidence grade

Reported asserted, with neither a test nor a traced descent

In the register

• Offspring recorded in this register; a cat may have others: Nikita'l Seymour

This directory is a working aid compiled from published charts, registry documents and breeder statements. It is not a register and it has no standing of any kind. The grade attaches to the animal, not to the line: a cat whose ancestor was genotyped is line-traced, not genotyped.