Mistral

Celeste line · DBE-CEL · both eyes blue, put down to a DBE variant or its line · Genotyped · also in its ancestry: Altai, early population, Blue Eyed Maine Coons (Markiss), DBE-ALT

Genealogy trace, one printable page carrying the proposed code

Under the variant field this directory proposes, this cat would read DBE 162p. The variant is attributed to this animal from the record rather than from a result on it. The proposal is set out in full here, and no registry issues this field today: it is computed from the record at each build and is not part of any registration.

How this cat is connected to the trait

1. Mistral
2. Lazuli, the sire of Mistral. genotyped DBE-CEL; a founder of this survey

That is one recorded parent link, and the animal at the end of it has a laboratory result, so what this cat could carry is not a guess about a line but a consequence of a test on a relative. Every step is a parent recorded in this register from a document; none of them is an assumption. The full genealogy is drawn below, and the sources for each animal are on its own page.

A determinant from each parent

This cat has a variant line above it on the sire’s side and a different one above it on the dam’s side. That is the only way a compound heterozygote is made, and it is the state in which harm is documented in this trait.

From the sire, Kaena

ALT (Nikita'l Seymour)

From the dam, Lazuli

CEL (Roxi)

This is not a statement that the cat is a compound heterozygote. Each parent passes one allele of the two it holds, so this kitten may carry the variant from neither side, from one, or from both. Nothing but a genotype distinguishes the three, and no animal in this class has been tested.

The other founders this cat descends from

This cat stands below more than one founder, by different parents. The chain above follows the line the record names. This one is reached by unbroken parent links from the other side.

ALT (Nikita'l Seymour)

1. Mistral
2. Kaena, the dam of Mistral
3. Nikita'l Seymour, XSH ns 03 23 68, the sire of Kaena. a founder of this survey; DBE-ALT, adopted by this survey

CEL (Roxi)

1. Mistral
2. Lazuli, the sire of Mistral
3. Roxi, XXH n 24 68, the sire of Lazuli. a founder of this survey; DBE-CEL, adopted by this survey

More than two determinants stand above this cat. Nothing in the descent says which it carries. Only a genotype settles it.

Save this cat as a PDF the connection, the genealogy and the source on one A4 landscape sheet, carrying this directory's name and address

More than one variant could be present in this cat

DBE-ALT and DBE-CEL. More than one variant could be present in this cat: DBE-ALT, DBE-CEL. It is not established that any of them is, and it is not established that two are. A dominant allele comes from a parent, and this cat's recorded ancestry carries an attribution of each. The attributions above it are on Kaena, Lazuli, Nikita'l Seymour, Roxi. A cat holding two is a compound heterozygote, which this survey records as the state associated with deaf and dead kittens, and nothing but a test distinguishes one from two.

Computed from the recorded parentage at every build, counting both the variants this survey adopts and the ones it records a source claiming and does not adopt. It is an upper bound and not a finding: it says what could be here, never what is.

What is flagged on this tree

1. PUSHOK. The Nikita'l material is now confirmed complete by three registry sheets read independently. Seymour's own sheet gives Pushok, HCL e 22 62, and Eliza, XSH ns 02 69, and nothing above either. Pheer-Ca's gives Roxi, xxh n 24 68, KZ, and March Nikita'l, eur n 03 62, and nothing above either. Markiss's gives all four. On all three sheets every cell above those four reads 'No information in the database' | the four foundation animals are the top of this material by registry record and not by absence of searching. Taken with the cattery listing, which holds the two founders and no descendants at all, the whole of what any registry holds on this cattery is now in this register. Nothing further can be obtained from pedigree material and the prefix should not be chased again | two codes stand on each side of Markiss before he is born. His sire Seymour is 68 out of a 62 and a 69; his dam Pheer-Ca is 69 out of a 68 and a 62. That is why every line descending from him carries both, and it is visible on the sheet without any inference at all
2. PUSHOK. Eye and coat, the strongest exclusion this register can make from a code. This cat is blue-eyed in both eyes and its recorded coat carries no white spotting code at all, is not dominant white and is not colourpointed. Nothing in the coat can pale an iris. A dominant blue eye is present and it is not the KIT odd-eye case and not the white-cat case. Its registry has entered no dominant eye code on it. Which variant is not deducible from a coat code and none is adopted: a genotype or a trace to a named founder would name it.
3. ELIZA. Homozygous, not compound heterozygote, in the breeder's own words, and the two are different claims. Her page says 'the last thing I expected from that pairing was a homozygous kitten'. Chart C4 writes 'DBE-CEL & DBE-ALT' beside him. Homozygous means two copies of one allele; compound heterozygote means one copy each of two different ones. This register held the second reading and the breeder states the first. Neither is a genotype and no laboratory result exists for him | the word homozygous cannot be right in its strict sense, and what it probably means is more interesting than if it were. ALT and CEL are established as separate variants in the published work this register holds: Abitbol and others 2024, 'Different Founding Effects Underlie Dominant Blue Eyes in the Domestic Cat', and 'A PAX3 insertion in the Celestial breed'. His dam KAENA runs to Nikita'l Seymour, who founds ALT; his sire LAZULI runs to ROXI, who founds CEL. A cat taking one copy from each is a compound heterozygote, one copy each of two different variants, and not a homozygote. The breeder is almost certainly using homozygous loosely, to mean two doses of dominant blue eye rather than two copies of one allele. That is exactly what chart C4 says when it writes 'DBE-CEL & DBE-ALT' Beside him, so the chart and the pedigree agree with each other and the breeder's word is the odd one out | and it is the case the breeding guidance warns about. Two dominant blue eye variants in one animal is precisely the mating the British Gems article, citing Abitbol, says should never be made. Miyuki is solid white and deaf. Whether that is the consequence of carrying both, or of the white spotting reaching him from three directions, is the thing no one can separate without a test | and the coat says be careful, which is why he was traced. Four generations above him, white spotting reaches him from three separate directions: Eliza, XSH ns 02 69, a harlequin and herself coded 69; March Nikita'l, eur n 03 62, a bicolour; and Nikita'l Seymour, XSH ns 03 23 68 on the PawPeds reading, also a bicolour. Miyuki is solid white and deaf. That is also exactly what a cat carrying a Great deal of white spotting looks like, and deafness is the classic consequence of white over the ear. His whiteness and his deafness are not by themselves evidence of a homozygous eye variant, and a homozygous white-spotting cat and a homozygous eye-variant cat cannot be told apart by looking | what else he could carry, asked and answered. He could carry heavy white spotting from Eliza, March Nikita'l and Seymour. He could carry the 69 that Eliza and Pheer-Ca both show. Nothing in his recorded ancestry suggests dominant white: no animal above him is coded w. Nothing suggests the pointed gene: no 33 anywhere. His four grandparents are Seymour, March Nikita'l, Roxi and an unnamed female the charts draw as '??' | his littermate Mochi is the control and is not deaf. Mochi is mostly white with a coloured patch, the Topaz panda pattern, and hears. Two kittens of one litter, both labelled the same by the chart, one deaf and one not. If the label were a genotype they should not differ, and the amount and placement of white is the obvious thing that does differ | he was neutered and placed, so no offspring will ever settle it. Only a test on him will
4. ELIZA. Variant taken over high white, on a ruling and not on a test. This cat carries dominant white, a van, harlequin or bicolour figure, or a point figure, any of which leaves enough unpigmented iris to account for a blue eye without PAX3. It also carries a variant or stands in a DBE line, and the holder ruled on 31 August 2026 that the variant is taken as the cause in that situation. The alternative is not closed and only a genotype closes it. A photograph is better evidence of extent than a code, so where one has been read the phenotype note should be preferred to this flag. Recorded so the ruling is visible on every animal it touches and can be reversed as a set. S_VARIANT_OVER_WHITE
5. Nikita'l Seymour. Breeding recommendations the page attributes to professor Marie abitbol of the vetagro research laboratory. The researcher and the subject are real and this register already holds her work: Abitbol and others 2024, 'Different Founding Effects Underlie Dominant Blue Eyes in the Domestic Cat', Animals 14(13):1845; Abitbol and others 2024, 'A PAX3 insertion in the Celestial breed and certain feline breeding lines with dominant blue eyes', Animal Genetics 55; Abitbol and others 2024, 'PAX3 haploinsufficiency in Maine Coon cats with dominant blue eyes and hearing loss resembling the human Waardenburg syndrome', G3; and Abitbol and others 2025, 'Dominant blue eyes in Maine Coon cats: new PAX3 variant and updated phenotypic data', Animal Genetics. But the list of recommendations below is the breeder's rendering of them and this register has not checked it against those papers. A real researcher being correctly named does not make a lay summary of her advice accurate. Recorded as the breeder states it, attributed as the breeder attributes it, and not adopted. Where this register needs the science it cites the papers directly. The list: do not breed DBE bloodlines with colourpoint or colourpoint carriers; with cats that have white, meaning bicolour, harlequin or van; with pure white cats; with cats born from DBE marriages that are born LATENT with orange eyes; or with recessive odd eyed. AND: 'Mixing, accidentally or not, a dominant cat to another dominant cat even if latent, can cause severe health issues in the first or future generations and should never be done' | the dangers named: 'Deafness (Altai, Topaz), cranial malformations (Ojos Azules, a breed abandoned by the LOOF and TICA in 2004 because of issues). Other things commonly seen in dominant odd eyed is a kinked tail or nose shapes that are strange, of form and small or not equal nostrils.' And: 'Dominant to dominant also seems to produce kittens with a large amount of white even if the parents are solid' | that last observation bears directly on Miyuki of aerlin. He is out of Kaena and Lazuli, both of dominant lines, his breeder calls him homozygous, and he is solid white and deaf where both parents carry only a chin patch. The page predicts exactly that outcome from exactly that mating, and it predicts it as a harm | the register records this as a breeder's statement of practice and as a health claim attributed to a named researcher. It does not endorse it, it has not verified the attribution, and it makes no recommendation about breeding | where this variant sits in PAX3. A third party compilation places DBE-ALT at INTRON 4, a noncoding variant. The register records the position and does not adopt it as its own finding: a schematic on a website is not a paper, and where this register needs the science it cites the papers directly. It is recorded because it is checkable, and because the position in the gene is the one thing about these variants that a breeder can never observe and a laboratory never reports on a result sheet. And the two kazakh variants sit in the same place. DBE-CEL and DBE-ALT are both placed in intron 4. This register has recorded from the start that the two were confused with each other for years, that breeder charts attribute one line to the wrong one of them, and that only a separate assay tells them apart. The shared location is the reason, and it is the first explanation of that confusion this register has been able to record rather than merely observe. S_LOCI_272
6. Nikita'l Seymour. Variant taken over high white, on a ruling and not on a test. This cat carries dominant white, a van, harlequin or bicolour figure, or a point figure, any of which leaves enough unpigmented iris to account for a blue eye without PAX3. It also carries a variant or stands in a DBE line, and the holder ruled on 31 August 2026 that the variant is taken as the cause in that situation. The alternative is not closed and only a genotype closes it. A photograph is better evidence of extent than a code, so where one has been read the phenotype note should be preferred to this flag. Recorded so the ruling is visible on every animal it touches and can be reversed as a set. S_VARIANT_OVER_WHITE
7. Nikita'l Seymour. Line and variant. The line Blue Eyed Maine Coons (Markiss) holds more than one variant across its records (DBE-ALT, DBE-CEL).
8. March Nikita'l, also given as Marta. Homozygous, not compound heterozygote, in the breeder's own words, and the two are different claims. Her page says 'the last thing I expected from that pairing was a homozygous kitten'. Chart C4 writes 'DBE-CEL & DBE-ALT' beside him. Homozygous means two copies of one allele; compound heterozygote means one copy each of two different ones. This register held the second reading and the breeder states the first. Neither is a genotype and no laboratory result exists for him | the word homozygous cannot be right in its strict sense, and what it probably means is more interesting than if it were. ALT and CEL are established as separate variants in the published work this register holds: Abitbol and others 2024, 'Different Founding Effects Underlie Dominant Blue Eyes in the Domestic Cat', and 'A PAX3 insertion in the Celestial breed'. His dam KAENA runs to Nikita'l Seymour, who founds ALT; his sire LAZULI runs to ROXI, who founds CEL. A cat taking one copy from each is a compound heterozygote, one copy each of two different variants, and not a homozygote. The breeder is almost certainly using homozygous loosely, to mean two doses of dominant blue eye rather than two copies of one allele. That is exactly what chart C4 says when it writes 'DBE-CEL & DBE-ALT' Beside him, so the chart and the pedigree agree with each other and the breeder's word is the odd one out | and it is the case the breeding guidance warns about. Two dominant blue eye variants in one animal is precisely the mating the British Gems article, citing Abitbol, says should never be made. Miyuki is solid white and deaf. Whether that is the consequence of carrying both, or of the white spotting reaching him from three directions, is the thing no one can separate without a test | and the coat says be careful, which is why he was traced. Four generations above him, white spotting reaches him from three separate directions: Eliza, XSH ns 02 69, a harlequin and herself coded 69; March Nikita'l, eur n 03 62, a bicolour; and Nikita'l Seymour, XSH ns 03 23 68 on the PawPeds reading, also a bicolour. Miyuki is solid white and deaf. That is also exactly what a cat carrying a Great deal of white spotting looks like, and deafness is the classic consequence of white over the ear. His whiteness and his deafness are not by themselves evidence of a homozygous eye variant, and a homozygous white-spotting cat and a homozygous eye-variant cat cannot be told apart by looking | what else he could carry, asked and answered. He could carry heavy white spotting from Eliza, March Nikita'l and Seymour. He could carry the 69 that Eliza and Pheer-Ca both show. Nothing in his recorded ancestry suggests dominant white: no animal above him is coded w. Nothing suggests the pointed gene: no 33 anywhere. His four grandparents are Seymour, March Nikita'l, Roxi and an unnamed female the charts draw as '??' | his littermate Mochi is the control and is not deaf. Mochi is mostly white with a coloured patch, the Topaz panda pattern, and hears. Two kittens of one litter, both labelled the same by the chart, one deaf and one not. If the label were a genotype they should not differ, and the amount and placement of white is the obvious thing that does differ | he was neutered and placed, so no offspring will ever settle it. Only a test on him will
9. ROXI. Breeding recommendations the page attributes to professor Marie abitbol of the vetagro research laboratory. The researcher and the subject are real and this register already holds her work: Abitbol and others 2024, 'Different Founding Effects Underlie Dominant Blue Eyes in the Domestic Cat', Animals 14(13):1845; Abitbol and others 2024, 'A PAX3 insertion in the Celestial breed and certain feline breeding lines with dominant blue eyes', Animal Genetics 55; Abitbol and others 2024, 'PAX3 haploinsufficiency in Maine Coon cats with dominant blue eyes and hearing loss resembling the human Waardenburg syndrome', G3; and Abitbol and others 2025, 'Dominant blue eyes in Maine Coon cats: new PAX3 variant and updated phenotypic data', Animal Genetics. But the list of recommendations below is the breeder's rendering of them and this register has not checked it against those papers. A real researcher being correctly named does not make a lay summary of her advice accurate. Recorded as the breeder states it, attributed as the breeder attributes it, and not adopted. Where this register needs the science it cites the papers directly. The list: do not breed DBE bloodlines with colourpoint or colourpoint carriers; with cats that have white, meaning bicolour, harlequin or van; with pure white cats; with cats born from DBE marriages that are born LATENT with orange eyes; or with recessive odd eyed. AND: 'Mixing, accidentally or not, a dominant cat to another dominant cat even if latent, can cause severe health issues in the first or future generations and should never be done' | the dangers named: 'Deafness (Altai, Topaz), cranial malformations (Ojos Azules, a breed abandoned by the LOOF and TICA in 2004 because of issues). Other things commonly seen in dominant odd eyed is a kinked tail or nose shapes that are strange, of form and small or not equal nostrils.' And: 'Dominant to dominant also seems to produce kittens with a large amount of white even if the parents are solid' | that last observation bears directly on Miyuki of aerlin. He is out of Kaena and Lazuli, both of dominant lines, his breeder calls him homozygous, and he is solid white and deaf where both parents carry only a chin patch. The page predicts exactly that outcome from exactly that mating, and it predicts it as a harm | the register records this as a breeder's statement of practice and as a health claim attributed to a named researcher. It does not endorse it, it has not verified the attribution, and it makes no recommendation about breeding
10. ROXI. Line and variant. The line Blue Eyed Maine Coons (Markiss) holds more than one variant across its records (DBE-ALT, DBE-CEL).
11. The unnamed female drawn as '??'. Unnamed, and expected to stay that way. The charts draw her as '??' and give her nothing else: no name, no breed, no colour, no code and no eye. She is the dam of the one DNA-genotyped DBE-CEL animal in this register and every position above her is empty. The holder of this material stated on 19 AUGUST 2026 that one parent of Lazuli will always be unknown. She is therefore not a gap awaiting a document and is not carried on any list of pedigrees to obtain. She is the animal whose absence from the record this survey is about, and the absence is now a settled fact about the record rather than an outstanding question
12. KAENA. Breeding recommendations the page attributes to professor Marie abitbol of the vetagro research laboratory. The researcher and the subject are real and this register already holds her work: Abitbol and others 2024, 'Different Founding Effects Underlie Dominant Blue Eyes in the Domestic Cat', Animals 14(13):1845; Abitbol and others 2024, 'A PAX3 insertion in the Celestial breed and certain feline breeding lines with dominant blue eyes', Animal Genetics 55; Abitbol and others 2024, 'PAX3 haploinsufficiency in Maine Coon cats with dominant blue eyes and hearing loss resembling the human Waardenburg syndrome', G3; and Abitbol and others 2025, 'Dominant blue eyes in Maine Coon cats: new PAX3 variant and updated phenotypic data', Animal Genetics. But the list of recommendations below is the breeder's rendering of them and this register has not checked it against those papers. A real researcher being correctly named does not make a lay summary of her advice accurate. Recorded as the breeder states it, attributed as the breeder attributes it, and not adopted. Where this register needs the science it cites the papers directly. The list: do not breed DBE bloodlines with colourpoint or colourpoint carriers; with cats that have white, meaning bicolour, harlequin or van; with pure white cats; with cats born from DBE marriages that are born LATENT with orange eyes; or with recessive odd eyed. AND: 'Mixing, accidentally or not, a dominant cat to another dominant cat even if latent, can cause severe health issues in the first or future generations and should never be done' | the dangers named: 'Deafness (Altai, Topaz), cranial malformations (Ojos Azules, a breed abandoned by the LOOF and TICA in 2004 because of issues). Other things commonly seen in dominant odd eyed is a kinked tail or nose shapes that are strange, of form and small or not equal nostrils.' And: 'Dominant to dominant also seems to produce kittens with a large amount of white even if the parents are solid' | that last observation bears directly on Miyuki of aerlin. He is out of Kaena and Lazuli, both of dominant lines, his breeder calls him homozygous, and he is solid white and deaf where both parents carry only a chin patch. The page predicts exactly that outcome from exactly that mating, and it predicts it as a harm | the register records this as a breeder's statement of practice and as a health claim attributed to a named researcher. It does not endorse it, it has not verified the attribution, and it makes no recommendation about breeding
13. LAZULI. Breeding recommendations the page attributes to professor Marie abitbol of the vetagro research laboratory. The researcher and the subject are real and this register already holds her work: Abitbol and others 2024, 'Different Founding Effects Underlie Dominant Blue Eyes in the Domestic Cat', Animals 14(13):1845; Abitbol and others 2024, 'A PAX3 insertion in the Celestial breed and certain feline breeding lines with dominant blue eyes', Animal Genetics 55; Abitbol and others 2024, 'PAX3 haploinsufficiency in Maine Coon cats with dominant blue eyes and hearing loss resembling the human Waardenburg syndrome', G3; and Abitbol and others 2025, 'Dominant blue eyes in Maine Coon cats: new PAX3 variant and updated phenotypic data', Animal Genetics. But the list of recommendations below is the breeder's rendering of them and this register has not checked it against those papers. A real researcher being correctly named does not make a lay summary of her advice accurate. Recorded as the breeder states it, attributed as the breeder attributes it, and not adopted. Where this register needs the science it cites the papers directly. The list: do not breed DBE bloodlines with colourpoint or colourpoint carriers; with cats that have white, meaning bicolour, harlequin or van; with pure white cats; with cats born from DBE marriages that are born LATENT with orange eyes; or with recessive odd eyed. AND: 'Mixing, accidentally or not, a dominant cat to another dominant cat even if latent, can cause severe health issues in the first or future generations and should never be done' | the dangers named: 'Deafness (Altai, Topaz), cranial malformations (Ojos Azules, a breed abandoned by the LOOF and TICA in 2004 because of issues). Other things commonly seen in dominant odd eyed is a kinked tail or nose shapes that are strange, of form and small or not equal nostrils.' And: 'Dominant to dominant also seems to produce kittens with a large amount of white even if the parents are solid' | that last observation bears directly on Miyuki of aerlin. He is out of Kaena and Lazuli, both of dominant lines, his breeder calls him homozygous, and he is solid white and deaf where both parents carry only a chin patch. The page predicts exactly that outcome from exactly that mating, and it predicts it as a harm | the register records this as a breeder's statement of practice and as a health claim attributed to a named researcher. It does not endorse it, it has not verified the attribution, and it makes no recommendation about breeding | tested against both new variants and excluded from both. Abitbol M, Eisele T and Lipovenko E, 'Additional PAX3 Variants for Dominant Blue Eyes in Cats', Animal Genetics 2026;57:e70199, Table 1 gives 'Celestial, 3, wild-type' for DBE-NAD, with two of the three also C/C for DBE-MARU. The breed's own variant is unaffected: this result separates it from the two variants named in 2026 and confirms that the Celeste carries neither. S_PAX3_2026_235 | where this variant sits in PAX3. A third party compilation places DBE-CEL at INTRON 4, a noncoding variant. The register records the position and does not adopt it as its own finding: a schematic on a website is not a paper, and where this register needs the science it cites the papers directly. It is recorded because it is checkable, and because the position in the gene is the one thing about these variants that a breeder can never observe and a laboratory never reports on a result sheet. And the two kazakh variants sit in the same place. DBE-CEL and DBE-ALT are both placed in intron 4. This register has recorded from the start that the two were confused with each other for years, that breeder charts attribute one line to the wrong one of them, and that only a separate assay tells them apart. The shared location is the reason, and it is the first explanation of that confusion this register has been able to record rather than merely observe. S_LOCI_272

A flag is not an error. It marks a place where two sources say different things, or where an attribution cannot be made on the evidence held.

The record

Register id

cel-11

Sex

male

Breed, as stated

Celeste line

Variant

DBE-CEL

Eye status

blue-variant: both eyes blue, put down to a DBE variant or its line

Eyes, in the source's words

drawn with two blue icons

Role

bridging

Relations named by the source

Kaena x Lazuli, 18 July 2016; mated in Canada to Cookie, Melodie, Ruby and Marguerite, four litters between 8 June and 20 July 2017

Litter key

celeste-2016

Country

Canada

The description held

silver tabby with white markings; went to the Miss Kitty cattery in Canada. Labelled DBE-CEL in red on chart C4. His dam Kaena is labelled DBE-ALT on the same chart and his sire Lazuli DBE-CEL

Evidence grade

Reported asserted, with neither a test nor a traced descent

In the register

• Parents: Kaena, Lazuli
• Offspring recorded in this register; a cat may have others: Nessy
• Littermates (celeste-2016): Miyuki of Aerlin, given on the Celeste charts as Miyuki, Mochi, Mavi of Aerlin, Merlin, Matcha, Mavi, Maidi, printed on the chart as Maidi with a diaeresis

This directory is a working aid compiled from published charts, registry documents and breeder statements. It is not a register and it has no standing of any kind. The grade attaches to the animal, not to the line: a cat whose ancestor was genotyped is line-traced, not genotyped.